The use of antidepressants has been associated with a reduced prevalence of periodontitis, according to a study published on October 29, 2025, in the Journal of Periodontology. The research, led by María Martínez from University Complutense in Madrid, examined data from 9,839 participants in the U.S. National Health and Nutrition Examination Survey conducted between 2009 and 2014.
Investigators found that the overall prevalence of periodontitis was significant, with 35.3% of participants exhibiting moderate cases and 11.1% suffering from severe cases. Notably, the study revealed a strong connection between antidepressant use and lower odds of developing periodontitis across various classifications, particularly in severe instances. For advanced periodontitis (stages III to IV), the adjusted odds ratio stood at 0.68, while the odds ratio for severe periodontitis was remarkably low at 0.41.
Understanding the Findings
These findings highlight a potentially protective effect of antidepressants against severe forms of periodontal disease. Ana Becil Giglio, president of the American Academy of Periodontology, remarked, “We have known for a long time that depression and gum disease can influence each other. This study adds an intriguing new layer, suggesting that antidepressant use may help protect against severe forms of periodontal disease.”
The interplay between mental health and oral health has garnered increasing attention in recent years. Depression and anxiety are known to impact overall health, potentially leading to neglect in personal care, which can exacerbate conditions like periodontitis.
Furthermore, the study’s large sample size lends credibility to its conclusions, suggesting that the relationship between antidepressants and periodontitis prevalence could be significant on a broader scale.
As healthcare professionals continue to explore the connections between mental and physical health, this research could pave the way for integrated treatment approaches that consider the implications of mental health medications on oral health.
For patients suffering from depression, the findings underscore the importance of discussing oral health with healthcare providers. The potential for antidepressants to offer dual benefits—supporting mental health while also protecting against periodontal disease—may influence treatment plans and patient outcomes.
The full study can be accessed in the Journal of Periodontology for those interested in delving deeper into the research findings.
