A research team from the College of Education and Health Professions at the University of Arkansas published a significant study on hydration and its effects on long-distance running, specifically at the 2024 Boston Marathon. The study, titled “Biomarkers of organ stress and injury following the Boston Marathon,” was released in the Journal of Applied Physiology, and aims to provide insights into the physiological challenges faced by marathon participants.
The research team, which included notable figures such as Brendon McDermott, Cory Butts, Abigail Morris, and Zachary McKenna, evaluated runners before and after the marathon to identify stress biomarkers related to kidney and gastrointestinal function. Their findings reveal that renal stress can persist regardless of hydration levels, prompting a need for athletes to adopt effective recovery strategies post-race.
Key Findings on Hydration and Recovery
“Our study reflects the considerable stress the body experiences during a moderately fast marathon,” said Brendon McDermott, who has devoted nearly 25 years to teaching athletic training and exercise science at the University of Arkansas. He emphasized that while hydration offers some protective benefits, it is not a complete safeguard against renal stress. “Runners should focus on recovery strategies, knowing that their gastrointestinal system and renal system will be challenged following a marathon,” he added.
McDermott, who directs the Heat and Hydration Optimization (H2O) Lab, specializes in preventive measures for heat-related illnesses and hydration. The comprehensive nature of the study has led to its inclusion in the National Library of Medicine, a vital resource for health professionals and researchers.
The research has also reached a broader audience through its feature in the health and nutrition newsletter “Run Long, Run Healthy,” published by Brady Holmer. The article, titled “The Crazy Effect a Marathon Has on Your Body,” aims to inform the public about the physiological implications of marathon running.
Future Research Directions
McDermott expressed his enthusiasm for the impact of their research, stating, “Having others read and show interest in our research brings the satisfaction that we need to continue answering scientific questions to help the population.” He acknowledged the support provided by the College of Education and Health Professions, highlighting the importance of funding, administrative assistance, and moral support in facilitating their research efforts.
Future laboratory studies are planned to further explore physiological questions related to distance running. The research team continues to build on their understanding of hydration and its effects, aiming to enhance the performance and health of athletes.
For more detailed insights, refer to the study: Zachary J. McKenna et al, Biomarkers of organ stress and injury following the Boston Marathon, Journal of Applied Physiology (2025). DOI: 10.1152/japplphysiol.00775.2025.
